End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest (NCT07632430) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest
United States3,500 participantsStarted 2024-01-01
Plain-language summary
The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2 (positive/negative) is a better predictor of patient survival to discharge. The secondary aim of this project is to identify significant predictors of neurologically intact patient survival as indicated by a cerebral performance category (CPC) score of 1-2.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* EHR's resulting from 9-1-1 response
* Adult patients (aged 18+ at time of cardiac event)
* experiencing out-of-hospital cardiac arrest (OHCA)
* transported by an agency under OMD oversight
* must have at least 2 EtCO2 values captured during care Exclusion Criteria
* EHR's resulting from inter-facility scheduled or unscheduled medical transfers
* pediatric patients (those aged \<18 at time of incident) or unknown age
* ROSC obtained prior to arrival of EMS
* insufficient vital sign data
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is observing ETCO2 trends during CPR in out-of-hospital cardiac arrest — could tracking that measurement during my resuscitation actually influence the decisions paramedics make in real time, or is it purely collected for research purposes?
2Since this trial is 'active but not recruiting,' is there any related study or protocol at this hospital that uses ETCO2 monitoring during cardiac arrest care that might still be relevant to my situation?
3The study is measuring survival to hospital discharge as its main outcome — based on what's already known about ETCO2 as a tool in cardiac arrest, does our local EMS team already use this kind of monitoring, and how might it affect my care if I were to go into cardiac arrest?
4This appears to be an observational study rather than a treatment trial — does that mean patients' care isn't changed by participation, and if so, how does the data collected here eventually translate into better prehospital treatment?
5Are there any current standard-of-care treatments or resuscitation protocols I should know about that are already supported by evidence, while research like this is still working to build the evidence base for ETCO2-guided decisions?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Survival to Hospital Discharge
Timeframe: 90 days
Trial details
NCT IDNCT07632430
SponsorOffice of the Medical Director for EMS in Oklahoma City and Tulsa