Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Livin… (NCT07631143) | Clinical Trial Compass
Not Yet RecruitingPhase 1/2
Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS
9 participantsStarted 2026-07-01
Plain-language summary
This study will look at the safety, tolerability and feasibility of a non-invasive treatment called Acute Intermittent Hypoxia (AIH) in people with Multiple Sclerosis (MS) at different stages of the disease course.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
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Group 1:
* People with a confirmed diagnosis of MS and advanced disability level (Expanded Disability Status Scale (EDSS) \>6.5 and \<9)
* Without relapse for at least 90 days prior
* Older than age 18
Group 2:
* People with a confirmed diagnosis of relapsing remitting MS
* Acute disabling relapse onset within the past 4 weeks. A disabling relapse will be defined as at least 1.0-point increase on the EDSS.
* Older than age 18
Group 3:
* People with a confirmed diagnosis of MS that is non-active and progressive (Primary or Secondary Progressive MS). Non-active will be defined as without MS relapse, new/enlarging or enhancing MRI lesions within the past 1 year.
* EDSS \<=6.5
* Older than age 18
Exclusion Criteria:
* Pregnancy
* Any of the following documented respiratory disorders: obstructive sleep apnea, chronic obstructive pulmonary disease, uncontrolled asthma, hypoxic pulmonary disease, respiratory infection in the previous 3 months
* Ischemic cardiac disease
* Cardiac arrhythmia
* Severe hypertension (\>160/100)
* Seizure disorders
* Medically unstable in another capacity
* Unable to provide informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
SpO2 < 78%, Heart rate < 50 beats per minute (bpm) or > 160 bpm
Timeframe: During the six AIH treatment session in weeks 1-4