Post-op Prednisone and Glucose Monitoring in TKA (NCT07630896) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Post-op Prednisone and Glucose Monitoring in TKA
United States104 participantsStarted 2026-07-01
Plain-language summary
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels monitored continuously.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Undergoing Primary Unicompartmental Knee Arthroplasty or Total Hip Arthroplasty
* Age 18 and above
Exclusion Criteria:
* Steroid therapy
* Narcotic use within past 3 months
* History of corticosteroid intolerance
* Pregnancy
* Uncontrolled diabetes
* Doesn't own smart phone
Drop Criteria:
\- 2nd dose of IV dexamethasone
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial involves taking prednisone after knee or hip replacement surgery — can you explain how a steroid like prednisone might help with my post-operative pain, and what the known risks are of using it right after a joint replacement?
2Since the trial is tracking both pain at rest and pain while walking, how does managing post-op pain in these two situations differ, and why would that matter for my recovery after my procedure?
3This study is listed as 'not yet recruiting' — do you know when it might open, and would waiting to potentially join it delay my surgery or affect my current treatment plan in any way?
4Because this is a Phase 4 trial, the drug itself has already been approved, but are there still things we don't fully know about using prednisone specifically in this post-surgical context that this study is trying to answer?
5Given that prednisone can affect blood sugar levels, and this trial involves glucose monitoring, is my personal health history — for example, any risk of diabetes — something that would make this trial a good or poor fit to discuss with my surgical team?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.