Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation (NCT07630857) | Clinical Trial Compass
RecruitingNot Applicable
Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation
China200 participantsStarted 2026-06-20
Plain-language summary
Atrial fibrillation (AF) is a common heart rhythm disorder. While catheter ablation is an effective treatment, many patients still experience AF recurrence after the procedure. One major reason is that the mechanisms that maintain AF are not fully understood. Research suggests that the outer layer of the heart (epicardium) may play an important role in keeping AF going. However, current mapping techniques have limitations in detecting electrical signals from both the inner and outer heart layers.
This study uses a different technique called unipolar voltage mapping, which may more accurately capture electrical signals from both heart layers. Specifically, we focus on a specific type of electrical signal called "QS potential" on unipolar mapping, which reflects breakthrough sites between the inner and outer heart layers.
In this interventional study, participants with AF undergoing catheter ablation will receive personalized ablation guided by unipolar QS-potential mapping. We aim to:
Explore the relationship between unipolar QS-potentials and AF maintenance and atrial remodeling Evaluate the effectiveness of QS-potential guided personalized AF ablation
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years and ≤ 80 years
* Documented diagnosis of atrial fibrillation (paroxysmal or persistent)
* Planned to undergo catheter ablation for AF (including patients with recurrent AF after prior ablation)
* Able and willing to provide written informed consent
* Able to complete scheduled follow-up visits (3 months post-ablation)
Exclusion Criteria:
* Left ventricular ejection fraction \< 35%
* Severe valvular heart disease (moderate to severe mitral stenosis or regurgitation)
* History of intracardiac thrombus
* Contraindication to anticoagulation
* Active infection or sepsis
* Pregnancy or breastfeeding
* Life expectancy \< 12 months due to comorbid conditions
* Participation in another interventional clinical trial within 30 days prior to enrollment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses something called unipolar voltage mapping to guide the ablation procedure — how is that different from the standard approach my doctor would normally use, and what does it mean for how my ablation would actually be performed?
2The trial is measuring whether patients stay free from atrial fibrillation at 3 months after ablation — is 3 months enough time to know if the procedure really worked for someone in my situation, or would my doctor want to follow me longer than that?
3Since this trial is listed as phase 'NA,' what does that tell us about how much safety and effectiveness data already exists for this particular mapping approach, and how should that factor into my decision?
4Would I still be a good candidate for standard AF ablation if I don't enroll in this trial, or is there a reason my doctor thinks a personalized mapping strategy like this one might be a better fit for me specifically?
5What does 'personalized' ablation based on voltage mapping actually mean in practice — could it result in a more extensive or longer procedure than a typical ablation, and are there any additional risks I should know about?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Freedom from Atrial Fibrillation Recurrence at 3 Months Post Ablation
Timeframe: 3 months (from month 1 to month 6 post-ablation)
Trial details
NCT IDNCT07630857
SponsorChina National Center for Cardiovascular Diseases