Supine vs. Prone PCNL for Large Renal Stones: A Randomized Trial in Yemen. (NCT07627503) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Supine vs. Prone PCNL for Large Renal Stones: A Randomized Trial in Yemen.
Yemen140 participantsStarted 2026-06-01
Plain-language summary
The goal of this clinical trial is to compare the safety, cost-effectiveness, and patient recovery of two different surgical positions for percutaneous nephrolithotomy (PCNL) in adults aged 18 to 70 years who have kidney stones larger than 2 cm. The main questions it aims to answer are:
* Does the supine (lying on the back) surgical position result in fewer early postoperative complications than the traditional prone (lying on the stomach) position?
* Does the supine position reduce the total surgery time, direct hospital costs, and postoperative pain?
Researchers will compare patients assigned to undergo PCNL in the supine position to those assigned to the prone position to see if the supine approach offers a safer, more cost-effective, and more comfortable recovery.
Participants will:
* Undergo standard PCNL surgery to remove their kidney stones in either the supine or prone position.
* Have their pain levels, surgery time, and any early surgical complications monitored during their hospital stay.
* Complete brief questionnaires regarding their overall surgical satisfaction and quality of life at 1 month and 3 months after the procedure.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18-70 years.
* Diagnosis of solitary or multiple renal stones with a cumulative diameter greater than 2 cm, confirmed by imaging (CT KUB).
* Patients eligible for standard PCNL (24-30 Fr).
* American Society of Anesthesiologists (ASA) physical status I-III.
* Willingness and ability to provide informed consent.
Exclusion Criteria:
* Patients with active urinary tract infection (UTI) not responding to antibiotics.
* Patients with bleeding diathesis or on anticoagulant therapy that cannot be safely discontinued.
* Patients with anatomical abnormalities of the kidney or urinary tract that preclude standard PCNL.
* Pregnant women.
* Patients with severe cardiopulmonary disease where general anesthesia or prolonged surgical positioning is contraindicated.
* Patients with a history of previous ipsilateral renal surgery.
* Patients unwilling or unable to comply with follow-up protocols.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence and Severity of Early Postoperative Complications