Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain Afte… (NCT07626463) | Clinical Trial Compass
RecruitingNot Applicable
Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery
China150 participantsStarted 2026-05-30
Plain-language summary
Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization.
Numerous studies have shown that glucocorticoids not only can achieve anti-inflammatory and analgesic effects by inhibiting inflammatory cytokines and inflammatory responses but also can prolong the duration of action of local anesthetics. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus diprospan is superior to ropivacaine alone in relieving postoperative pain for adults undergoing laparoscopic surgery. The investigators also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.
Who can participate
Age range
18 Years – 64 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;
. Ages 18 to 64 years old;
. American Society of Anesthesiologists (ASA) physical status of I-III;
. Patients must be able to understand nature and potential personal; consequences of the clinical trial and cooperation with follow-up investigations;
. signing of the informed consent form.
Exclusion criteria
. History of allergies to experimental drugs such as opioids or steroids;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing a local anesthetic injection with ropivacaine and a steroid called Diprospan made before the incision — how does that approach compare to the standard pain management I would already receive after my laparoscopic procedure?
2The main thing this trial is measuring is how much IV morphine-equivalent rescue pain medication I need in the first 48 hours after surgery — does that mean my pain relief might be less predictable than with a standard approach, and what would happen if I need more pain medication than expected?
3Since this trial is listed as Phase NA, what does that tell us about how much safety and effectiveness data already exists for this specific combination of ropivacaine and Diprospan used this way, and are there any known risks from the steroid component I should be aware of?
4This trial covers several different laparoscopic surgeries — appendectomy, cholecystectomy, and hernia repair — does the type of laparoscopic surgery I'm having affect whether this intervention might be more or less appropriate for my specific situation?
5What would my pain management plan look like if I chose not to participate in this trial, and is there a standard-of-care alternative that might be just as effective for my recovery?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Intravenous Morphine Equivalents of Rescue Analgesic Medications Within 48 Hours Postoperatively
. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics;
. Use analgesic drugs within 24 hours before surgery;
. Patients undergoing steroid therapy;
. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;