The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill … (NCT07624721) | Clinical Trial Compass
CompletedNot Applicable
The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill Patients
Belgium1,416 participantsStarted 2026-04-01
Plain-language summary
With this study, the investigators want to find out how well different stages of acute kidney injury (AKI), match with the actual filtering ability of the kidneys in very sick adults in the intensive care unit (ICU). Kidney function will be measured using a urine test that estimates how much waste the kidneys can clear from the blood.
The investigators will also compare two ways of diagnosing and staging AKI: one based on how much urine a person makes, and the other based on blood creatinine levels (a waste product that rises when kidney function worsens). In addition, the investigators will examine how factors that can be changed (such as treatments or medications) and factors that cannot be changed (such as age or existing health conditions) may affect this relationship.
Finally, the investigators will look at whether drops in kidney function are linked to problems like high potassium levels in the blood and a buildup of acid in the body.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Admission ICU of Ghent university hospital
* Availability of at least one serum creatinine clearance
Exclusion Criteria:
* chronic RRT before ICU admission
* RRT during ICU
* Missing or incomplete data preventing KDIGO AKI classification
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study has already been completed, would it be possible for my doctor to access the findings about how creatinine clearance relates to AKI severity, and could those findings change how my kidney function is monitored right now?
2This study looked at critically ill patients specifically — does my current condition or level of illness match the type of patients included, and is that relevant to how my doctor interprets my own creatinine clearance results?
3The trial measured the connection between KDIGO AKI staging and creatinine clearance — can my doctor explain what KDIGO staging means for my situation and whether my kidneys are currently being assessed using that same approach?
4Because this was an observational study rather than a treatment trial, it was gathering information rather than testing a therapy — does my doctor know of any treatment trials for acute kidney injury that might be worth considering based on what studies like this have found?
5Are there standard-of-care monitoring tools or protocols for acute kidney injury that my care team is already using, and how does the kind of research done in this study inform those day-to-day decisions about my kidney health?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The association between KDIGO AKI stage and measured creatinine clearance.
Timeframe: from ICU admission until ICU discharge (average 4 days)