Advanced Platelet-Rich Fibrin and Coronally Advanced Flap for Gingival Recession Treatment (NCT07624591) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Advanced Platelet-Rich Fibrin and Coronally Advanced Flap for Gingival Recession Treatment
Vietnam11 participantsStarted 2025-08-01
Plain-language summary
The goal of this clinical trial is to learn if adding a natural healing material works better to treat receding gums in adults. Receding gums is a condition where the gum tissue pulls back and exposes the tooth root. The main questions it aims to answer are:
* Does the addition of this healing material help cover the exposed root better than the standard surgery?
* Does the material help the gum tissue heal faster and become thicker? Researchers will compare a standard gum surgery alone to the standard gum surgery combined with Advanced Platelet-Rich Fibrin (A-PRF). A-PRF is a healing material made directly from the participant's own blood during the surgery. This comparison will help see if A-PRF improves the final cosmetic look and gum health.
Participants will:
* Have their blood drawn at the start of the surgery to create the A-PRF material.
* Receive the gum surgery with or without the A-PRF material. Visit the clinic for checkups and gum measurements at 1 week, 2 weeks, 4 weeks, 1 month, 3 months, and 6 months after the surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18 years or older.
* Presence of 1 to 2 gingival recession defects requiring treatment, classified as RT1 (Cairo 2011).
* Gingival recession defects located in the anterior or premolar regions of the maxilla or mandible.
* Gingival thickness ≥ 1 mm. Keratinized tissue width ≥ 2 mm. Probing depth ≤ 2 mm.
* Good oral hygiene, demonstrated by a mean Gingival Index (GI) ≤ 1 and a mean full-mouth Plaque Index (PI) ≤ 1.
Exclusion Criteria:
* Patients with systemic diseases affecting wound healing (e.g., diabetes mellitus, coagulation disorders).
* Pregnant or lactating women.
* Patients with a smoking habit.
* Teeth with interproximal bone loss.
* Severely malpositioned teeth.
* Presence of caries or cervical restorations at the experimental site.
* History of previous periodontal surgery at the selected sites.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean Root Coverage (MRC)
Timeframe: Baseline, 1 month, 3 months, and 6 months post-surgery
Trial details
NCT IDNCT07624591
SponsorUniversity of Medicine and Pharmacy at Ho Chi Minh City