Renal SWE as a Predictor After Pediatric Pyeloplasty for UPJO (NCT07624019) | Clinical Trial Compass
RecruitingNot Applicable
Renal SWE as a Predictor After Pediatric Pyeloplasty for UPJO
Egypt84 participantsStarted 2026-05-06
Plain-language summary
Ureteropelvic junction obstruction is an important cause of hydronephrosis and potentially reversible renal functional impairment in children. Although open pyeloplasty is an effective standard treatment, the degree of postoperative renal functional recovery varies between patients.
This prospective observational cohort study will evaluate whether renal cortical shear wave elastography can predict renal functional recovery after open pyeloplasty in children with unilateral primary ureteropelvic junction obstruction. Renal cortical shear wave elastography will be assessed before surgery and during follow-up, and the change in elastography values will be compared with renal isotope findings after surgery.
The primary objective is to evaluate the predictive value of the change in renal cortical shear wave elastography from baseline to 3 months after surgery for isotope-defined renal functional recovery at 6 months after open pyeloplasty.
Who can participate
Age range
6 Months – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Children aged 6 months to 18 years.
* Diagnosis of unilateral primary ureteropelvic junction obstruction.
* Planned for open dismembered pyeloplasty.
* Availability of preoperative renal ultrasonography, renal cortical shear wave elastography, and diuretic renography.
* Written informed consent obtained from parent or legal guardian.
Exclusion Criteria:
* Bilateral ureteropelvic junction obstruction.
* Secondary ureteropelvic junction obstruction.
* Previous ipsilateral upper urinary tract surgery.
* Associated major urinary tract anomalies likely to independently affect renal function, including vesicoureteral reflux, megaureter, duplex system, posterior urethral valves, or ectopic kidney.
* Active urinary tract infection at the time of assessment.
* Known intrinsic renal parenchymal disease unrelated to obstruction.
* Inability to obtain reliable shear wave elastography measurements.
* Incomplete planned follow-up.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Predictive Accuracy of 3-Month Change in Renal Cortical SWE for 6-Month Functional Recovery
Timeframe: Baseline to 6 months after open pyeloplasty