Prospective Observational Study of Smartphone-Based AI Self-Monitoring During Non-Surgical Treatment for Thyroid Eye Disease (THYROSCOPE)

Inclusion Criteria: * Adults aged 19 years or older with a clinical diagnosis of thyroid eye disease (TED). * Patients with TED scheduled to initiate active non-surgical treatment, including but not limited to intravenous methylprednisolone, oral corticosteroids, radiotherapy, or biologic therapy. * Able to undergo baseline clinical assessment prior to initiation of the planned treatment course and expected routine follow-up evaluation during treatment, including an end-of-treatment assessment. * Able and willing to use their own smartphone to complete the study application-guided symptom questionnaire and capture standardized frontal facial images throughout the study period. * Willing to perform at least weekly home-based image capture and symptom reporting during the treatment course. * Able to participate in routine in-person follow-up visits and expected to provide at least two clinic-matched assessments, including baseline and at least one post-baseline assessment. * Voluntarily provides written informed consent to participate in the study. Exclusion Criteria: * Severe eyelid deformities, facial deformities, or other facial/periocular conditions that may interfere with standardized image acquisition or reliable AI-based image analysis. * Unable to use the study application or smartphone-based image capture procedure adequately for protocol-required self-monitoring. * Undergoing or planning to undergo surgical treatment for TED as the primary treatment modality during…