The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal T… (NCT07623629) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion.
Egypt52 participantsStarted 2026-01-03
Plain-language summary
The goal of this clinical trial is to learn which rinsing of root canals method works best to lower pain after a root canal in adults. The study focuses on participants aged 20 to 40 with an infection in a lower back tooth (mandibular first molar) and a small area of bone loss at the root tip.
The main questions it aims to answer are:
Does the type of tool used to rinse the tooth root canal change how much pain a participant feels after treatment?
Does the cleaning method lower the number of painkillers a participant needs to take?
Researchers will compare four different rinsing tools-ranging from a standard needle to advanced vacuum and vibration devices-to see if using suction and sound waves can lower pain levels.
Participants will:
Receive a complete root canal treatment in a single visit
Be randomly assigned to one of four cleaning groups (standard rinse, vibration, vacuum, or a combination of both)
Rate their pain on a scale of 0 to 10 at five specific times: before the visit, and at 6, 12, 24, and 48 hours after treatment
Record how many painkiller tablets (Ibuprofen) they take during the two days following the procedure
Who can participate
Age range
20 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Lower first molar Classification of root canal configuration according to weine classification: -
* Distal root: any type of root canal configuration given that the portal of exit is through only one apical foramen
* Mesial root: any type of root canal configuration given that the portal of exit is through only one apical foramen(18).
* Patient with mild pre-operative pain with pain score from 0-3
* Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II).
* The age range is between 20 to 40 years.
* Patients have restorable lower permanent molars that were diagnosed with symptomatic apical periodontitis with small to moderate periapical lesion.
* Positive patient's acceptance for participating in the study.
* Patients able to sign informed consent.
Exclusion Criteria:
* Patients with systemic conditions that may affect pain perception (e.g., fibromyalgia, chronic pain disorders)
* Patients currently taking or taken analgesics or anti-inflammatory medications before the trial in the last 12 hours.
* Pregnant or lactating females.
* Psychologically disturbed patients.
* Patients with a history of allergy to any medication used in the study are excluded.
Teeth that have:
* Periodontally affected with grade 2 or 3 mobility.
* Not restorable teeth.
* Abnormal anatomy and calcified canals.
* Previous root canal treatment.
* Any patient that matched the inclusion criteria, however had an u…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
postoperative pain
Timeframe: Before treatment, 6 hours after treatment, 12 hours after treatment, 1 day after treatment, 2 days after treatment.