Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Co… (NCT07623590) | Clinical Trial Compass
RecruitingNot Applicable
Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography
France30 participantsStarted 2025-04-07
Plain-language summary
Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the end of breathing.
The goal of this study is to learn if continuous anterior chest compression works as well as electrical impedance tomography for positive expiratory pressure titration.
Researchers will compare the two methods for each patient, in a randomly determined order : continuous anterior chest compression and electrical impedance tomography.
Participants will :
* have a pep titration with both techniques
* be included in the study for 28 days
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* Moderate to severe ARDS according to the Berlin criteria
* Patient receiving sedation and continuous curarization
* Free and informed consent from the patient or their loved one
Exclusion Criteria:
* ECMO
* Pneumothorax
* Chest trauma in the last 3 months
* Uncontrolled shock (noradrenaline \> 5 mg/h)
* Pregnant or breastfeeding woman
* Protected adult within the meaning of the law
* Lack of social security
* Patient under AME
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
PEPCTAC
Timeframe: Day 0
2
PEPCAC
Timeframe: Day 0
3
PEPEIT
Timeframe: Day 0
Trial details
NCT IDNCT07623590
SponsorCentre Hospitalier Saint Joseph Saint Luc de Lyon