Effectiveness of Two Different Desensitizing Dental Varnishes (NCT07622043) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effectiveness of Two Different Desensitizing Dental Varnishes
Liechtenstein66 participantsStarted 2026-08
Plain-language summary
Dental varnishes are commonly used to relieve dentin hypersensitivity by forming a protective film that occludes dentinal tubules and reduces fluid flow. This clinical investigation aims to compare the desensitizing effect of a fluoride containing varnish with a fluoride free placebo varnish. Primary and secondary objectives include evaluating short and long term reductions in dentinal hypersensitivity, assessing patient reported outcomes and daily experiences, and monitoring the varnish's tolerability and safety.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Informed Consent signed by the subject
* Age: 18-65 years
* Hypersensitivity assessment scale ≥ Grade 2 in
* two non-neighboring teeth in different quadrants
* The affected teeth are/have: vital, caries-free, received no restorations within the last month
* No change in medication anticipated over the next 3 months (e.g. due to upcoming surgery etc.)
Exclusion Criteria:
* Contraindications and limitations of the MD as described in the instructions for use.
* Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring)
* Pregnant or other vulnerable subjects
* Participants with severe systemic disease
* Enrolment of employees of the dental clinic of Ivoclar Vivadent AG
* Recent change in medication concerning Analgesics, NSAIDs, psychotropic drugs, other medications that may alter pain perception
* Intake of analgesics prior to appointment
* Professional desensitizing therapy in the last 3 months
* Bleaching procedures in the last 4 weeks
* Confounding dental conditions at test sites: defective or extensive restorations, abutment teeth for prostheses, recent restorations, pulpitis/periapical pathology.
* Current or recent use of desensitizing toothpastes or mouthrinses (i.e. products specifically marketed for the treatment of dentin hypersensitivity) within 4 weeks prior to enrolment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.