High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Phase II Cardiac Re… (NCT07619664) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Phase II Cardiac Rehabilitation
Pakistan66 participantsStarted 2026-06
Plain-language summary
This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty. A total of 66 participants will be randomly allocated into two groups: HIIT (n=33) and MICT (n=33). The intervention will be conducted 3 times per week using treadmill-based exercise protocols under heart rate monitoring. Primary outcomes include changes in left ventricular ejection fraction, functional capacity measured by 6-minute walk test, and lipid profile parameters before and after intervention. Secondary assessment includes health-related quality of life (HRQoL). The study aims to determine which exercise modality provides superior cardiovascular and functional improvement in stable cardiac patients during supervised rehabilitation.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18-60 years.
* Diagnosed with stable coronary artery disease confirmed by angiography, stress testing, or echocardiography.
* Left ventricular ejection fraction ≥45%.
* Functional NYHA Class I or II.
* Medically cleared by a cardiologist to participate in exercise (including recent ECG or stress test if necessary).
* Lightly active lifestyle prior to study (not involved in structured exercise programs).
Exclusion Criteria:
* Unstable angina or recent myocardial infarction (within the past 6 weeks).
* Uncontrolled hypertension (systolic BP \>180 mmHg or diastolic BP \>110 mmHg).
* Severe valvular heart disease, arrhythmias, or left ventricular dysfunction (EF \<35%).
* Musculoskeletal disorders (e.g., severe osteoarthritis, recent fractures, or surgeries) preventing safe participation in exercise.
* Neurological disorders affecting mobility or safe exercise (e.g., stroke, Parkinson's disease).
* Uncontrolled diabetes mellitus (HbA1c \>9% or recent hypoglycemia).
* Any other condition judged by the investigator to make participation unsafe.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Left Ventricular Ejection Fraction
Timeframe: Baseline and at 12 weeks after intervention
2
Functional Capacity
Timeframe: Baseline and at 12 weeks after intervention