Not Yet RecruitingNot Applicable

Motion Sickness Severity and Sensorimotor Performance

41 participantsStarted 2026-06-01

Plain-language summary

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Individuals aged between 18 and 40 years. * Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF). * Normal hearing acuity. * No history of acute or chronic vestibular disease, other than motion sickness. * Normal or corrected-to-normal vision. * Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests. Exclusion Criteria: * Presence of any physical or orthopedic problem that could interfere with testing. * History of acute or chronic instability, unsteadiness, or vertigo. * Severe visual impairment. * History of prior ear surgery. * Presence of any neurological condition or disorder. * History of migraines. * Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives). * Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Motion Sickness Severity (Graybiel Score)

Timeframe: 1 hour

Static Balance

Timeframe: 1 hour

Dynamic Balance Performance

Timeframe: 1 hour

Trial details

NCT IDNCT07619469

SponsorIstinye University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-02

View on ClinicalTrials.gov More Motion Sickness trials

Plain-language summary

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.