Dermocosmetic Evaluation of Propolis Ointments in Atopic-Prone Dry Skin (NCT07618234) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Dermocosmetic Evaluation of Propolis Ointments in Atopic-Prone Dry Skin
Syria30 participantsStarted 2026-04-15
Plain-language summary
The goal of this clinical trial is to learn if propolis ointments work to improve dry, atopic-prone skin in adults. Propolis is a natural substance made by honeybees. It will also learn about the safety of these ointments.
The main questions it aims to answer are:
Does propolis ointment lower dryness, scaling, and roughness better than a base ointment with no propolis? Is there a difference between crude propolis and ethanolic extract of propolis (EEP)?
Researchers will compare three ointments to see if they improve skin condition:
A propolis ointment made with 3% ethanolic extract A propolis ointment made with 5% crude propolis A base ointment with no propolis (look-alike)
Participants will:
Apply the ointment to dry skin areas twice a day for 4 weeks Visit the clinic 4 times: for screening, at the start, at week 2, and at week 4 Have their skin checked by a researcher using a standard dryness score Answer questions about skin comfort, itching, and satisfaction Have a patch test before starting to check for allergy to propolis
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18-60 years
* Atopic-prone dry skin or mild xerotic skin condition
* Mild-to-moderate skin dryness, scaling, roughness, and mild itching
* No acute inflammatory skin disease
* Ability to attend follow-up visits and comply with application instructions
* Signed informed consent form
Exclusion Criteria:
* Known allergy to propolis, honey, or bee products
* Known allergy to lanolin
* Acute eczema flare, infected dermatitis, psoriasis, seborrheic dermatitis, fungal infections, herpes simplex, or scabies
* Pregnancy or breastfeeding
* Recent use of systemic corticosteroids (within 2 weeks)
* Recent use of immunosuppressants (within 4 weeks)
* Recent use of biologics (within 3 months)
* Recent use of topical corticosteroids (within 1 week)
* Recent use of topical calcineurin inhibitors (within 1 week)
* Recent phototherapy (within 2 weeks)
* Severe systemic diseases not under control
* Poor compliance or inability to cooperate
* Use of other skin products during the study period
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.