Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Si… (NCT07618182) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment
116 participantsStarted 2026-07-05
Plain-language summary
This randomized controlled trial aims to evaluate the effect of two different concentrations of sodium hypochlorite (2.5% and 5.25%) on post-operative pain following single-visit root canal treatment. A total of 116 participants requiring primary endodontic treatment will be randomly allocated into two groups according to irrigant concentration. Post-operative pain will be assessed using a 100-mm Visual Analog Scale at 6, 12, 24, and 48 hours after treatment. The study seeks to determine the concentration that provides optimal disinfection with minimal patient discomfort.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients aged 18-60 years Systemically healthy individuals Permanent teeth with closed apices requiring primary root canal treatment Teeth diagnosed with symptomatic/asymptomatic irreversible pulpitis or pulpal necrosis Patients able to understand the Visual Analog Scale Patients willing to provide informed consent and complete follow-up
Exclusion Criteria:
* Uncontrolled systemic diseases Pregnant or breastfeeding women Allergy to sodium hypochlorite or local anesthetics Previously endodontically treated teeth Teeth with root resorption, vertical root fracture, or open apex Severe periodontal disease or mobility Use of analgesics, antibiotics, or anti-inflammatory drugs within previous 7 days
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing two different concentrations of sodium hypochlorite during root canal treatment — can you explain what sodium hypochlorite is used for in a root canal, and how the concentration might affect my pain afterward?
2Since this trial is not yet recruiting, how long might it be before it opens to patients, and would waiting for it delay any treatment I need now?
3The trial is described as 'Phase NA,' which often applies to procedural or device studies rather than drug trials — does that change what we know about the safety profile compared to a standard root canal using the concentration your practice already uses?
4If I were to consider this trial once it opens, what would a single-visit root canal involve for me specifically, and are there any reasons based on my dental situation that might make one sodium hypochlorite concentration a better fit than the other?
5Would going ahead with a standard root canal now, using whichever concentration your practice typically uses, be a better option for managing my pain, rather than waiting to see if this trial becomes available?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post-Operative Pain Following Single-Visit Root Canal Treatment
Timeframe: At 6 hours, 12 hours, 24 hours, and 48 hours after completion of treatment.
2
Post-Operative Pain Score
Timeframe: 6 hours, 12 hours, 24 hours, and 48 hours after treatment
Trial details
NCT IDNCT07618182
SponsorCollege of Physicians and Surgeons Pakistan