L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones (NCT07617909) | Clinical Trial Compass
RecruitingPhase 2
L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones
Egypt120 participantsStarted 2026-05-06
Plain-language summary
This study will compare L-citrulline and tamsulosin as medical expulsive therapy for adults with single distal ureteral stones.
Eligible participants with a single distal ureteral stone measuring 5 to 10 mm will be randomly assigned to receive either oral L-citrulline 750 mg twice daily or oral tamsulosin 0.4 mg once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.
Participants will be followed weekly for up to 4 weeks. The main outcome is stone expulsion within 4 weeks. The study will also assess time to stone expulsion, pain episodes, analgesic use, need for additional intervention, and adverse events.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 to 60 years.
* Single distal ureteral stone.
* Stone size 5 to 10 mm.
* Normal renal function.
* Controlled pain.
* Willingness to comply with follow-up for 4 weeks.
* Written informed consent.
Exclusion Criteria:
* Fever or active urinary tract infection.
* Severe hydronephrosis.
* Solitary kidney.
* Pregnancy.
* Previous ureteric surgery.
* Multiple ureteral stones.
* Indication for urgent surgical intervention.
* Known hypersensitivity or contraindication to L-citrulline or tamsulosin.
* Inability to complete follow-up.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.