Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners (NCT07617571) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners
Egypt30 participantsStarted 2026-06-01
Plain-language summary
Background: Orthodontic forces induce tissue reactions by triggering perturbations from orthodontic appliances, which lead to the modelling and remodelling of alveolar bone. Despite the growing popularity of 3D-printed aligners, no studies have compared their effects on bone metabolism in comparison with thermoformed aligners. Aim: This study aims to assess bone metabolism in patients undergoing treatment with 3D-printed aligners versus thermoformed aligners.
Who can participate
Age range
18 Years – 25 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Minor malocclusion (2 to 4 mm of crowding) .
* Patients in need for Antero-posterior expansion and labial tipping of incisors without interproximal reduction
* No use of anti-inflammatory drugs or antibiotics in the past 6 months.
* Periodontal parameters of gingival index \<1 and no pocketing with a generalized pocketing depth of \<3mm.
* Radiographic parameters of no crestal bone loss.
* No history of smoking.
Exclusion Criteria:
* Signs of inflammation of the gingiva, and periodontitis.
* Systemic conditions (kidney disease, HIV, and liver disease).
* Teeth missing or poor oral hygiene.
* Bone disease e.g.; osteoporosis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.