Efficacy and Safety of DNN.31.19.026 for Ocular Hypertension or Primary Open-Angle Glaucoma

Inclusion Criteria: * Participants of either sex, aged ≥18 years; * Participants diagnosed with ocular hypertension or primary open-angle glaucoma according to the Clinical Protocol and Therapeutic Guidelines for Glaucoma; * Participants requiring ocular hypotensive treatment in one or both eyes, for whom the use of combination topical ocular hypotensive medications is appropriate for intraocular pressure (IOP) reduction. Exclusion Criteria: * Participants diagnosed with primary open-angle glaucoma with no prior treatment history for the disease; * Participants with a cup-to-disc ratio \>0.8 (horizontal or vertical); * Participants with any other clinically significant ocular disease that, in the investigator's opinion, may interfere with the evaluation of study efficacy and safety variables; * Participants with ocular infection or inflammation within 3 months prior to the screening/run-in visit; * Participants with a history of trabeculoplasty (within the last 6 months) or surgical procedures for IOP reduction; * Participants with a history of ocular surgery within 6 months prior to the screening/run-in visit; * Participants with any corneal abnormality that may affect IOP measurement; * Participants with respiratory or pulmonary disorders, such as asthma or chronic obstructive pulmonary disease (COPD); * Participants with the following cardiac conditions: sinus bradycardia, sinoatrial block, second- or third-degree atrioventricular block, overt heart failure, or cardioge…