This ClinicalTrials.gov entry corresponds to the Neural Basis of Human Working Memory protocol approved under Vanderbilt University Medical Center IRB #251231. This study investigates the neural activity underlying human working memory, via local field potential changes (macro level) and/or single neuronal spiking changes (micro level) from depth electrodes placed for invasive seizure monitoring. Subjects will complete neurocognitive tasks while neural recordings are collected. Some patients will complete neurocognitive tasks while stimulation is applied via depth electrodes. Further understanding the neural activity changes underlying normal and impaired working memory may help to identify novel diagnostic methods and treatments for impaired working memory and may support the use of stimulation for treatment of memory disorders.
Age range
18 Years
Sex
ALL
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Local field potential changes in response to working memory tasks
Timeframe: During patient's epilepsy monitoring stay, approximately 20-30 minutes
Single unit neuronal spiking changes in response to memory tasks
Timeframe: During patient's epilepsy monitoring stay, approximately 20-30 minutes
Behavioral performance changes with simulation
Timeframe: During patient's epilepsy monitoring stay, approximately 20-30 minutes