Intravascular Ultrasound guidaNce versuS angIoGrapHy Guidance in Patients With ST-segment Elevati… (NCT07616024) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Intravascular Ultrasound guidaNce versuS angIoGrapHy Guidance in Patients With ST-segment Elevation Myocardial Infarction
China2,488 participantsStarted 2026-06-01
Plain-language summary
STEMI represents the subtype of ACS with the worst prognosis, associated with high mortality and an elevated risk of complications. The use of IVI guidance holds the potential to reduce the incidence of MACE. In previous studies, there has been limited research on intravascular imaging in the context of primary revascularization procedures for STEMI, and no large-scale cohort study has compared the differences in clinical outcomes between IVI-guided and angiography-guided primary revascularization. Therefore, we conducted this large-scale randomized controlled trial to compare IVI-guided primary PCI versus coronary angiography-guided primary PCI in patients with STEMI.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients diagnosed with acute ST-segment elevation myocardial infarction (STEMI) who have an indication for emergency interventional therapy;
. Subjects who are eligible to undergo primary percutaneous coronary intervention (PCI);
. Subjects or their authorized family members voluntarily agree to participate in the clinical trial and sign the written informed consent form;
. The IVUS catheter is expected to pass through the target lesion to complete the examination.
Exclusion criteria
. Patients with cardiogenic shock or severe heart failure (Killip class IV);
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing ultrasound guidance versus standard X-ray guidance during the stenting procedure for a heart attack — given my specific situation, does my doctor think one approach already has a clear advantage for me, or is that genuinely still an open question?
2Since this trial hasn't started recruiting yet, how long might it realistically be before I could even enroll, and is waiting for that opportunity the right choice compared to getting treated now with whatever guidance method my care team would use today?
3The trial is measuring 'target vessel failure,' which means problems with the treated artery over time — can my doctor explain what that looks like in practice, and how important that outcome is for someone in my position?
4Because this study is listed as Phase NA, meaning it's comparing two existing techniques rather than testing a new drug, what does my doctor already know about the safety and effectiveness of intravascular ultrasound guidance from existing evidence?
5If I'm not able to participate in this trial or it's not yet open, would my doctor consider using intravascular ultrasound guidance during my procedure anyway, or is that something that depends on the specific hospital and equipment available?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.