A Study to Test the Safety and Blood Levels of PMG1016 in Healthy Adults

Inclusion Criteria: * Participants must be in good health based on medical history, physical exam, vital signs, ECG, and lab results at screening, as judged by the PI. * BMI 17.5-32.0 kg/m² and body weight 50-100 kg for males or 45-100 kg for females * No clinically significant lab abnormalities (hematology, coagulation, biochemistry, urinalysis) per PI discretion * Females: Must be non-pregnant, non-lactating, and use double contraception (condom + hormonal method/vaginal ring/IUD) through study completion, unless surgically sterile, postmenopausal, or in same-sex relationships. Negative pregnancy tests required. No oocyte donation for 90 days post dose. * Males: Must be surgically sterile, abstinent, or use condoms plus a highly effective method for female partners. Vasectomized males without proof of azoospermia must use condoms with WOCBP partners. No sperm donation for 90 days post dose. Exclusion Criteria: * History or evidence of any clinically significant medical condition (e.g., cardiovascular, gastrointestinal, endocrine, hematologic, psychiatric, renal, musculoskeletal, infectious, neurological, or other major disease) as determined by the PI. * A PR \<40 or \>100 bpm or mean SBP \>140 mmHg or DBP \>95 mmHg (based on triplicate supine measurements after 5 minutes' rest). * Mean QTcF \>450 ms (males) or \>470 ms (females) at Screening; one repeat triplicate ECG allowed at PI discretion * Any clinically significant ECG abnormalities (rhythm, conduction, morphology…