Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease (NCT07613840) | Clinical Trial Compass
RecruitingNot Applicable
Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease
United States484 participantsStarted 2025-04-29
Plain-language summary
The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore blood flow to their legs.
The main questions it aims to answer are:
* Does the personalized plan lower the rate of blood clots in the treated leg one year after the procedure?
* Does the personalized plan lower rates of amputation, repeat procedures, bleeding, and death compared to standard treatment?
Researchers will compare the personalized TARGET plan which uses a blood test to tailor each person's blood clot prevention medication to the standard treatment to see if the personalized approach works better.
Participants will:
* Be randomly assigned to either the personalized TARGET plan or standard treatment after their procedure
* Have blood tests at 1 week and at 1, 3, 6, 9, and 12 months after their procedure
* Have medications adjusted based on blood test results if assigned to the TARGET group
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with a named arterial extremity injury or named vessel revascularization for atherosclerosis requiring open and/or closed revascularization.
* Patients at the age of 18 or older
Exclusion Criteria:
* Patients who are younger than 18 years old
* Known pregnancy (females of childbearing potential will have a pregnancy test prior to surgery as per standard of care)
* Prisoners, defined as those who have been directly admitted from a correctional facility.
* No atherosclerosis
* Subject has active stomach ulcers
* Subject has severe hepatic impairment
* Subject has a recent history of intracranial hemorrhage. If the patient has a history of cerebral hemorrhage with no new central nervous system disease of \>1 year, the study team will consult with the
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of Arterial Thrombosis in the Treated Limb