Probiotic-Uricase Complex Preparation for Improving Uric Acid Metabolism in Patients With Hyperuricemia

Inclusion Criteria: * Age 18-60 years. * Men with serum uric acid levels \> 420 μmol/L on 2 separate occasions (not on the same day), women with serum uric acid levels \> 360 μmol/L on 2 separate occasions (not on the same day). * Participants must sign an informed consent form and be able to cooperate with sample collection. Exclusion Criteria: * A history of or current presence of a clearly defined organic intestinal disease, such as intestinal malignant tumor, inflammatory bowel disease, intestinal obstruction, or intestinal polyp. * Concurrent severe systemic diseases, including severe cardiovascular or cerebrovascular disease (eg., myocardial infarction within the past 6 months, NYHA Class III-IV heart failure, or uncontrolled hypertension), significant liver function abnormalities (ALT or AST \> 2 times the upper limit of normal), moderate-to-severe renal insufficiency (eGFR \< 45 mL/min/1.73 m²) or uncontrolled diabetes (HbA1c ≥ 9%). * Use of antibiotic, probiotic preparation, or other drugs that may significantly alter the gut microbiota within 4 weeks prior to enrollment, or those requiring continued use of such drugs during the study. * Women who are pregnant or lactating, or who plan to become pregnant during the study. * Participants with severe tophus or gouty nephropathy. * Participants who have participated in another clinical trial within 3 months prior to enrollment. * Participants with other health problems that render them unsuitable for enrollment.