Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
Australia25 participantsStarted 2026-08
Plain-language summary
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4. The primary questions it aims to answer are:
1. Is ABR1 safe to use as an intraarticular injection for participants with knee osteoarthritis?
2. What medical problems do participants have after receiving a single injection of ABR1?
Participants will receive a single injection of ABR1 to the knee with osteoarthritis. Participants will
1. Keep a stable pain treatment regimen
2. Visit the clinic at 1 week, 4 weeks, 8 weeks, and 12 weeks post injection
3. Keep a diary of their symptoms and number of times they use a rescue medication for their knee pain.
Who can participate
Age range
40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male or female at least 40years of age
. Knee OA with Kellgren-Lawrence (KL) Grade 2 to 4 of the target knee on X-ray
. Inadequate pain relief with 1st line treatment, consisting of any of the following
. stable dose NSAIDs for at least the past 30 days OR
. use of NSAID treatment is contraindicated
. Target knee pain on most days (at least 15 days per month in the preceding month)
. Symptomatic knee OA with moderate to severe pain (NRS ≥4 and \<9 on Numeric Rating Scale (NRS) with target knee significantly worse than the other knee with a minimum difference of 2-point between knees.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of adverse events
Timeframe: from the day receiving study intervention (day 0) to 12 weeks after study intervention
. Other significant knee pathologies of target knee from medical history or radiographic method(s)
. Severe malalignment \> 10 degree in the target knee (either varus or valgus) measured using standardized knee x-ray at screening or based on previous medical records
. Severe inflammatory arthritis or other joint disease with warm, red, and swollen knee in the target knee
. History of knee surgery or significant knee trauma of target knee in the past 12 months
. Received intraarticular injection in the targeted knee joint within the past 6 months
. Knee surgery or intraarticular injection in the target knee planned in the next 8 months