Physiological Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP (NCT07611409) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Physiological Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP
Argentina20 participantsStarted 2025-09-10
Plain-language summary
This experimental physiologic study is conducted to determine the effect of different mechanical ventilation settings (in terms of positive end-expiratory pressure) on patients receiving mechanical ventilation with expiratory flow obstruction and autoPEEP. The main question it aims to answer In patients with autoPEEP, what is the effect of applying external PEEP on gas exchange and the lung emptying pattern in patients with total ventilatory support? Participants must comply:
\- Age \> 17 years.
* Invasive mechanical ventilation (endotracheal tube or tracheostomy) in controlled mode, with SpO2 \> 90%, for more than 12 hours.
* No contraindications for abdominal compression.
* Presence of autoPEEP greater than 3 cmH2O measured in mechanical ventilation with total support and ZEEP.
* Total mechanical respiratory support, without respiratory muscle activity (inspiratory or expiratory).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Age \> 17 years. Invasive mechanical ventilation (endotracheal tube or tracheostomy) in controlled mode, with SpO2 \> 90%, for more than 12 hours.
No contraindications for abdominal compression. AutoPEEP greater than 3 cmH2O measured during mechanical ventilation with full support and ZEEP.
Full mechanical respiratory support, with no respiratory muscle activity (inspiratory or expiratory).
\-
Exclusion Criteria:
Cardiovascular instability: Hypotension (MAP \< 60 mmHg), hypertension (SBP \> 180 mmHg), heart rate \< 40 bpm or \> 150 bpm.
Refusal to participate in the study by a family member (without signed informed consent).
Evidence of air leak: Pneumothorax, subcutaneous emphysema, pneumomediastinum. Intracranial hypertension (ICP \> 20 mmHg). Pregnant patient. Body Mass Index greater than 40 kg/m².
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
To evaluate the expiratory time constant as a function of external PEEP.