Not Yet RecruitingPhase 2/3

Colchicine for the Prevention of Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Single-Center, Strategy-Stratified, Randomized, Double-Blind, Placebo-Controlled Trial

400 participantsStarted 2026-06

Plain-language summary

Post-operative atrial fibrillation after coronary artery bypass grafting (CABG)

Who can participate

Age range

20 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 20 years or older scheduled to undergo elective coronary artery bypass grafting (CABG), including either off-pump CABG or on-pump CABG. * Ability to receive oral study medication before and after surgery. * Provision of written informed consent before randomization. Exclusion Criteria: * History of atrial fibrillation or atrial flutter before surgery. * Severe renal impairment (estimated glomerular filtration rate \<30 mL/min/1.73 m²) or chronic dialysis. * Severe hepatic dysfunction. * Known hypersensitivity or previous severe adverse reaction to colchicine. * Pregnancy or breastfeeding. * Current use of strong CYP3A4 or P-glycoprotein inhibitors that cannot be safely discontinued or substituted. * Any condition judged by the investigators to interfere with study participation or safety assessment.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Incidence of new-onset atrial fibrillation within 14 days after CABG surgery

Timeframe: From the day of surgery through postoperative day 14.

Trial details

NCT IDNCT07611019

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-07

Contact for this trial

Jeng-Wei Chen, MD

+886-2-2312-3456 ext. 265081 chenjw@ntu.edu.tw

View on ClinicalTrials.gov More Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) trials

Who can participate

Age range

20 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.