Not Yet RecruitingNot Applicable

Periodontal Inflammation and Epigenetics in Obese Individuals

United States40 participantsStarted 2026-05-25

Plain-language summary

The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are: • To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged ≥18 years, * No history of periodontal therapy in the last 6 months, * No use of tobacco, * No history of pregnancy lactation or contraceptive medication. * Need to have a minimum of 20 teeth. Exclusion Criteria: * Had antimicrobial/antiviral therapy in the previous 3 months, * History of uncontrolled diabetes, * History of rheumatoid arthritis, * History of osteoporosis, * History of oral cancer, * Currently taking hormonal contraception, * If pregnant or lactating currently or prior 6 months, * Subjects on current weight loss drugs * If planning weight reduction surgery during the time of the study * Any other condition, disease or therapy with documented influence on oral inflammation and/or oral microbial environment.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Host-specific epigenetic signatures

Timeframe: Baseline/Day 1

Inflammatory cytokine profiles

Timeframe: Baseline/Day 1

Periodontal microbial composition

Timeframe: Baseline/Day 1

Trial details

NCT IDNCT07610902

SponsorLouisiana State University Health Sciences Center in New Orleans

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-30

Contact for this trial

Vinayak M Joshi, PhD, MS

15049418280 vjosh1@lsuhsc.edu

View on ClinicalTrials.gov More Obesity trials

Plain-language summary

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.