Acute mesenteric ischemia (AMI) is a rare but life-threatening condition associated with high mortality and major diagnostic challenges due to nonspecific clinical presentation and limited reliable biomarkers. Critically ill patients in the intensive care unit (ICU) are at particularly high risk of non-occlusive mesenteric ischemia (NOMI), a subtype of AMI characterized by impaired mesenteric perfusion without large-vessel occlusion. Despite advances in imaging, the diagnosis of NOMI remains difficult, and data specifically focusing on ICU patients with suspected AMI are limited. This prospective observational multicenter study aims to identify independent predictors of transmural NOMI among ICU patients with suspected AMI. In addition, the study will describe demographics, comorbidities, clinical presentation, laboratory findings, diagnostic imaging, management strategies, and outcomes among ICU patients with NOMI, other forms of AMI, and patients with suspected but unconfirmed AMI. Consecutive adult ICU patients in whom clinical suspicion of AMI arises during ICU stay will be included across Estonian regional hospitals. The study is a local continuation of the international AMESI study, with a specific focus on critically ill ICU patients.
Age range
18 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Predictors of transmural necrosis in NOMI - age-adjusted Charlson comorbidity index
Timeframe: Baseline
Predictors of transmural necrosis in NOMI patients - SOFA score
Timeframe: Baseline
Predictors of transmural necrosis in NOMI patients - GRV
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - bloody stool.
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - cardiac arrest.
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - RRT
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - WBC.
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - CRP
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - lactate
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - pneumatosis intestinalis
Timeframe: Baseline
Predictors of transmural ischemia in NOMI patients - bowel wall enhancement
Timeframe: Baseline