Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental Anesthesia (NCT07608900) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental Anesthesia
80 participantsStarted 2026-08
Plain-language summary
This study will evaluate whether pre-emptive local anesthesia reduces sevoflurane consumption during pediatric day-case dental treatment performed under general anesthesia.
Children aged 4 to 12 years scheduled for elective dental treatment under general anesthesia will be included. Participants will be assigned to either receive pre-emptive local anesthesia before the dental procedure or receive no pre-emptive local anesthesia. General anesthesia will be standardized using sevoflurane, low fresh gas flow, endotracheal intubation, and bispectral index monitoring.
The main outcome will be sevoflurane consumption expressed as mL/kg/hour. Secondary outcomes will include anesthetic agent uptake, time from sevoflurane discontinuation to extubation, and estimated carbon dioxide-equivalent emissions.
The aim is to determine whether pre-emptive local anesthesia can reduce volatile anesthetic requirement and improve early recovery while maintaining adequate anesthetic depth in children undergoing dental general anesthesia.
Who can participate
Age range
4 Years – 12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Children aged 4 to 12 years
* Scheduled for elective day-case dental treatment under general anesthesia
* ASA physical status I or II
* Planned sevoflurane-based general anesthesia
* Planned oral endotracheal intubation
* Eligibility for standardized low-flow anesthesia with fresh gas flow of 1 L/min
* Eligibility for BIS-guided sevoflurane titration
* Written informed consent obtained from a parent or legal guardian
Exclusion Criteria:
* Age younger than 4 years or older than 12 years
* ASA physical status III or higher
* Emergency dental procedures
* Known allergy or contraindication to sevoflurane
* Known allergy or contraindication to amide local anesthetics, articaine, or epinephrine
* Known or suspected malignant hyperthermia susceptibility
* Significant cardiovascular, respiratory, hepatic, renal, or neurological disease requiring non-standard anesthetic management
* Chronic opioid or sedative use
* Planned airway management other than oral endotracheal intubation
* Dental procedures in which withholding pre-emptive local anesthesia is considered clinically inappropriate for safety or hemostasis
* Refusal of participation by parent or legal guardian
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Sevoflurane Consumption in mL/kg/hour
Timeframe: Intraoperative period, from initiation of sevoflurane administration to sevoflurane discontinuation; assessed at the end of each procedure