A First-in-human Phase I Study to Evaluate EMB-15 in Patients With Locally Advanced or Metastatic… (NCT07607054) | Clinical Trial Compass
RecruitingPhase 1
A First-in-human Phase I Study to Evaluate EMB-15 in Patients With Locally Advanced or Metastatic Solid Tumors.
China50 participantsStarted 2026-05-26
Plain-language summary
The primary purpose of this study is to evaluate safety and tolerability profile of EMB-15, identify the recommended Phase 2 dose(s) (RP2Ds) for EMB-15. Pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and the anti-tumor activity of EMB-15 will also be assessed.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Exclusion criteria
. Any prior ALPP/ALPG targeting therapy
. Has received anticancer therapy, radiotherapy, or investigational drug within \< 5 half-lives or 4 weeks (whichever is shorter) prior to study treatment;
. Active autoimmune disease or history of autoimmune disease
. Concurrent malignancy \< 5 years prior to study entry
. active infection
. Severe or uncontrolled cardiovascular disease requiring treatment
. Other severe medical conditions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
incidence and severity of adverse events as assessed by CTCAE v6.0 and ASTCT.
Timeframe: Screening up to follow-up (30 days after the last dose)
2
Incidence of serious adverse events (SAE)
Timeframe: Screening up to follow-up (30 days after the last dose)
3
Incidence of dose interruptions
Timeframe: Screening up to follow-up (30 days after the last dose)
4
Dose intensity
Timeframe: Screening up to follow-up (30 days after the last dose)
5
The incidence of DLTs during the DLT evaluation period.
Timeframe: First infusion to the end of Cycle 1 (each cycle is 28 days)