Laryngeal cancer can affect speaking, swallowing, and breathing. Treatment selection depends on accurately defining tumor spread within the larynx, particularly invasion of the paraglottic space, thyroid cartilage, and subglottic region. Understaging may lead to insufficient treatment and recurrence, whereas overstaging may result in unnecessarily aggressive surgery and impaired quality of life. CT and MRI are routinely used for local staging, but both have limitations. Conventional CT may have limited soft-tissue and cartilage contrast, while MRI is more time-consuming, motion-sensitive, and not feasible in all patients. Photon-counting CT (PCCT) is a new CT technology offering higher spatial resolution, improved tissue contrast, and reconstructions at different energy levels. This study evaluates whether PCCT performed during phonation, while the patient produces a sustained sound, can improve local staging of laryngeal cancer. Phonation may better separate and display laryngeal structures, improving detection of tumor extension. The main hypothesis is that optimized phonation PCCT reconstructions can assess tumor spread more accurately than standard CT and may approach MRI performance. Participants undergo PCCT as part of routine preoperative imaging. Images are reconstructed using different settings and reviewed by radiologists for image quality and tumor extension. When surgery is performed, imaging findings are compared with surgical and histopathological results. The study aims to identify the most accurate PCCT reconstruction strategy to support better treatment planning in laryngeal cancer.
Age range
18 Years
Sex
ALL
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Diagnostic Accuracy of Phonation Photon-Counting CT (PCCT) for Local Tumor Extension
Timeframe: From completion of baseline phonation PCCT imaging to histopathological correlation, assessed up to 12 weeks.
Identification of the Optimal PCCT Reconstruction for Local Staging
Timeframe: From completion of baseline phonation PCCT imaging to histopathological correlation, assessed up to 12 weeks.