Assessment of Venous Insufficiency and Clinical Features in Lipedema (NCT07603076) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Assessment of Venous Insufficiency and Clinical Features in Lipedema
Turkey (Türkiye)82 participantsStarted 2026-05-20
Plain-language summary
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.
Who can participate
Age range
18 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female participants aged 18 years or older
* Clinically diagnosed lipedema according to established diagnostic criteria
* Ability to provide written informed consent
* Ability to complete clinical assessments and questionnaires
Exclusion Criteria:
* History of lower extremity venous surgery or sclerotherapy
* Known peripheral arterial disease
* Secondary lymphedema or other causes of lower extremity edema
* Active infection, cellulitis, or inflammatory disease affecting the lower extremities
* Pregnancy or postpartum period
* Neurological, rheumatological, or musculoskeletal disorders significantly affecting lower extremity function
* Malignancy or severe systemic disease
* Inability to undergo venous Doppler ultrasonography
* Inability to understand or complete study assessments and questionnaires
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Presence of Venous Reflux on Doppler Ultrasonography
Timeframe: Baseline
Trial details
NCT IDNCT07603076
SponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey