Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE

Inclusion Criteria: * Subject with multi-vessel disease * Having successful index PCI and planned staged procedure within 1-6 weeks to complete revascularization * Subjects ≥21 years of age * Office systolic blood pressure at index procedure and/or staged procedure (systolic blood pressure \>140 mmHg) while taking 2 or more antihypertensive drugs * Subject agrees to have all study procedures performed, and is competent and willing to provide written, informed consent to participate in this clinical study prior to staged procedure Exclusion Criteria: * \- Contraindication for RDN outlined by IFU * Acute MI at time of the staged PCI procedure (AMI at time of the index PCI is allowed) * Subject has undergone prior renal denervation. * Subject has renal artery anatomy that is ineligible for RDN treatment per Symplicity Spyral™ IFU * Known secondary cause (e.g., renal artery stenosis, primary aldosteronism, pheochromocytoma, Cushing's syndrome, or other identifiable etiologies). * Severe renal failure (eGFR \<30 ml/min/1.73 m²) * Known LVEF \<30% * Known history of polycystic kidney disease, unilateral kidney, or undergone renal transplant * Mechanical circulatory support during PCI * Subject is under judicial protection, tutorship or curatorship * Failure of index procedure * Acute MI, severe renal failure, need for mechanical circulatory support, or legal incapacity between the index and staged procedures resulting in loss of eligibility.