MRI and Local Anesthesia (NCT07602686) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
MRI and Local Anesthesia
United States102 participantsStarted 2026-07-15
Plain-language summary
The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult age 18 or older
* Health status of American Society of Anesthesiologists (ASA) class 1 or 2
* Able to provide informed consent
* Able to appear in person at OMRIC on the days indicated for the study
Exclusion Criteria:
* ASA class 3 or higher
* Pregnant patients
* Taking any medication that would affect pain perception or interact with local anesthetic
* Allergic/history of adverse reaction to local anesthetic or any component in the local anesthetic
* Paresthesia in the area of innervation of Cranial Nerve V3
* Active infection or abscess in the oral and maxillofacial region
* History of temporomandibular disorder, maximum incisal opening less than 15mm
* History of recent dental trauma (within the past 6 months)
* Dental hypersensitivity
* Claustrophobia and/or conditions of anxiety or motion disorder (for MRI purposes)
* Metallic, electronic, or magnetic implants or devices classified as MR Unsafe or Conditional by the American College of Radiology
* Unable to give informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Patient reported sensation - 5min
Timeframe: 5 minutes after the nerve block
2
Patient reported sensation - 1 hour
Timeframe: within 1 hour of the nerve block
3
Ability to sense light touch
Timeframe: within 1 hour of the nerve block
4
Ability to sense pressure
Timeframe: within 1 hour of the nerve block
5
Ability to sense direction of touch (only if can sense VonFrey fibers)
Timeframe: within 1 hour of the nerve block
6
Ability to distinguish sharp versus dull (only if can sense VonFrey fibers)