The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation. In addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.
Age range
18 Years – 64 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
circulant microRNA
Timeframe: At baseline, at 24 hours, 1 month, 3 months
tissue microRNA
Timeframe: At baseline
Metabolomic analysis
Timeframe: At baseline, 24 hours, 1 month, 3 months