Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Underg… (NCT07601256) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
China480 participantsStarted 2026-08-15
Plain-language summary
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥ 18 years.
. Diagnosis of sepsis according to Sepsis-3.0 (highly suspected or confirmed infection with acute increase in SOFA score ≥ 2).
. Scheduled to undergo surgery under general aaesthesia for source control or sepsis-related operative management.
Exclusion criteria
. Already intubated prior to entering the operating room.
. Chronic home ventilator dependence (e.g., severe chronic obstructive pulmonary disease) before surgery.
. Personal or family history of malignant hyperthermia.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing inhaled anesthesia to intravenous anesthesia in septic patients having surgery — if I need surgery soon, which type of anesthesia is my care team currently planning for me, and could participating in this study affect that decision?
2The trial is not yet recruiting, so it may be some time before I could even enroll — given that I have sepsis now, is waiting for this trial a realistic option, or should we be focused on treatment decisions right now?
3The main thing this trial is measuring is how many days after surgery a patient can breathe without a ventilator — does my current lung function or severity of sepsis put me at higher risk for needing ventilator support, and is that something this trial is specifically designed to help?
4Since this trial is listed as Phase NA, meaning it may be more of a comparative or observational study rather than an early-phase safety trial, what does my doctor think is already known about the safety of inhaled versus intravenous anesthesia in patients with sepsis and lung injury like mine?
5Are there established standard-of-care guidelines for which type of anesthesia is preferred in septic patients with lung injury, and would my doctor follow those regardless of this trial, or is this genuinely an open question that a study like this is trying to answer?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Ventilator-free days at 7 days after surgery
Timeframe: From the surgery to the 7th day
Trial details
NCT IDNCT07601256
SponsorSixth Affiliated Hospital, Sun Yat-sen University