A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1… (NCT07600736) | Clinical Trial Compass
RecruitingPhase 2
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric Participants With KCNT1-related Epilepsy
United States45 participantsStarted 2026-05-18
Plain-language summary
This trial will evaluate the safety, tolerability, pharmacokinetics, and clinical activity of ABS-1230 compared with placebo in participants with KCNT1-related epilepsy
Who can participate
Age range
1 Month – 21 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 1 month to \<22 years
* Clinician-confirmed diagnosis of KCNT1-related epilepsy
* Has an average of at least 4 countable motor seizures per week
* Is taking no more than 6 antiseizure medications (ASM) and is able to keep stable doses of ASMs for the duration of Part 1 or Part 2
Exclusion Criteria:
* Is currently taking phenytoin, carbamazepine, stiripentol, or quinidine
* Has a medical condition that, in the opinion of the investigator, would limit the participant's ability to participate in the study or might compromise participant safety or interfere with evaluation of the study drug.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Part 1: Safety and tolerability of ABS-1230 (incidence and severity of adverse events)
Timeframe: Measured from Day 1 to End of Study or Early Termination (up to 12 weeks)
2
Part 2: Efficacy of ABS-1230
Timeframe: Measured from Day 1 to End of Study or Early Termination (up to 12 weeks)
3
Part 3: Safety and tolerability of ABS-1230 (incidence and severity of adverse events)
Timeframe: Measured from Day 1 of Part 3 to End of Study or Early Termination (up to 1 year)