The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum. The study will be conducted on 48 subjects divided into two groups of 24: a control group receiving total intravenous anesthesia (TIVA) and an experimental group receiving TIVA combined with a bilateral intermediate cervical plexus block. Investigators hypothesized that a combination of bilateral intermediate cervical plexus block and total intravenous anesthesia (TIVA) would reduce the surgical stress response, as measured by salivary and blood biomarkers, compared to TIVA alone in patients undergoing total thyroidectomy. Should the research confirm the hypothesis, it will provide an objective scientific argument for including the block in standard anesthetic protocols for total thyroidectomy surgeries, with the ultimate goal of reducing the surgical stress response and ensuring faster patient recovery.
Age range
18 Years
Sex
ALL
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Serum Cortisol Concentration
Timeframe: Preoperative baseline, 1 hour postoperative, 24 hours postoperative and 48 hours postoperative
Salivary Cortisol Concentration
Timeframe: Preoperative baseline, 1 hour and 24 hour postoperative
Serum IL-6 Concentration
Timeframe: Preoperative baseline, 1 hour, 24 hours and 48 hours postoperative
Salivary IL-6 Concentration
Timeframe: Preoperative baseline, 1 hour and 24 hours postoperative
Serum Alpha-amylase Activity
Timeframe: Preoperative baseline, 1 hour, 24 hours and 48 hours postoperative
Salivary Alpha-amylase Activity
Timeframe: Preoperative baseline, 1 hour and 24 hours postoperative
Serum CRP Concentration
Timeframe: Preoperative baseline, 1 hour, 24 hours and 48 hours postoperative
Serum Glucose Concentration
Timeframe: Preoperative baseline, 1 hour, 24 hours and 48 hours postoperative
Total Lukocyte Count
Timeframe: Preoperative baseline, 1 hour, 24 hours and 48 hours postoperative