Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A C… (NCT07600411) | Clinical Trial Compass
RecruitingNot Applicable
Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A Cohort Study
Egypt100 participantsStarted 2026-03-11
Plain-language summary
The goal of this clinical trial is to learn if the type of weight-loss surgery (sleeve gastrectomy or gastric bypass) affects binge eating, depression, and anxiety in adults with severe obesity. The main questions it aims to answer are:
Does sleeve gastrectomy lead to different changes in binge eating compared with gastric bypass?
Does the type of surgery lead to different changes in depression and anxiety symptoms?
Researchers will compare people who have sleeve gastrectomy with those who have gastric bypass to see if there are differences in binge eating, depression, and anxiety levels up to 12 months after surgery.
Participants will:
Complete questionnaires about eating habits, mood, anxiety, general health, and body image before surgery.
Undergo either a sleeve gastrectomy or a gastric bypass operation (both are standard care).
Follow a standard post-surgery diet plan.
Attend follow-up visits at 1 week, 2 weeks, 1 month, and then monthly for 12 months, where they will complete the same questionnaires again.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 60 years
* Body Mass Index (BMI) ≥ 35 kg/m² without comorbidities, OR BMI ≥ 30 kg/m² with at least one obesity-related medical comorbidity (e.g., type 2 diabetes, hypertension, obstructive sleep apnea, dyslipidemia)
* Patient is generally fit for laparoscopic surgery and general anesthesia as determined by preoperative evaluation
* Patient agrees to comply with postoperative lifestyle changes (dietary modifications and follow-up schedule)
* Willing and able to provide written informed consent
Exclusion Criteria:
* Age \< 18 years or \> 60 years
* Inability or unwillingness to adhere to postoperative lifestyle changes
* Contraindication to surgery: American Society of Anesthesiologists (ASA) class IV or higher
* History of receiving radiotherapy or chemotherapy for cancer treatment
* Active substance use disorder or uncontrolled severe psychiatric illness that would impair ability to comply with study procedures (e.g., active psychosis, severe suicidal ideation)
* Pregnant or breastfeeding women (pregnancy test performed preoperatively per institutional protocol)
* Previous bariatric surgery (revisional surgery excluded)
* Untreated thyroid disorder (e.g., hypothyroidism or hyperthyroidism)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Composite Mental Health Score (Simple Sum)