Gingival TrxR1 Expression in Periodontal Health and Periodontitis (NCT07598942) | Clinical Trial Compass
CompletedNot Applicable
Gingival TrxR1 Expression in Periodontal Health and Periodontitis
Turkey (Türkiye)60 participantsStarted 2023-08-30
Plain-language summary
This study aims to investigate the role of the thioredoxin system in the development and progression of periodontitis. Researchers will examine the levels of specific antioxidant markers, such as thioredoxin reductase 1 (TrxR1), glutathione (GSH), and malondialdehyde (MDA), in gingival tissue samples collected from healthy individuals and patients with different stages of periodontal disease. The goal is to determine if TrxR1 levels can serve as a potential biomarker for diagnosing the severity and activity of periodontitis.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Being between the ages of 18 and 70.
* Having no known systemic disease.
* Non-smokers.
* No history of medication or supplement use in the last 3 months.
* For the Periodontitis groups: Interdental clinical attachment loss (CAL), probing pocket depth (PPD), and radiographic bone loss according to 2017 World Workshop criteria.
Exclusion Criteria:
* Smoking.
* Pregnancy or breastfeeding.
* Presence of a systemic disease (e.g., diabetes mellitus, hypertension, rheumatoid arthritis, cancer, thyroid disorders, kidney or lung diseases).
* History of any periodontal surgical procedure within the last 6 months.
* Use of medication or supplements within the last 3 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study measured TrxR1 mRNA levels in gum tissue from people with periodontitis — what does thioredoxin reductase 1 actually do, and what might its expression levels tell us about the oxidative stress happening in my gums?
2Since this trial is already completed, have the results been published, and if so, does the data suggest that TrxR1 expression could eventually be used as a marker to track how severe my periodontitis is?
3The study focused on oxidative stress as part of periodontitis — based on what's being learned from research like this, are there any current treatment approaches that target oxidative stress in the gums that might be relevant to my care?
4Because this was an observational study measuring gene expression rather than testing a treatment, what does my doctor think the practical next steps in this line of research might be, and could findings like these influence how periodontitis is treated in the future?
5My periodontitis involves ongoing inflammation — would my doctor recommend I look into any active clinical trials that are actually testing treatments targeting oxidative stress pathways, building on what observational studies like this one are finding?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.