This study aims to compare the diagnostic accuracy of rapid antigen detection tests (RDTs) for SARS-CoV-2 using nasal swab insertion depths of 2 cm versus 4 cm. The study is an investigator-initiated, randomized clinical trial conducted at a public COVID-19 test center in Copenhagen, Denmark. Following enrollment, participants complete a questionnaire regarding symptoms and vaccination status. Participants are randomized in a 1:1 ratio to one of two sampling sequences: either a 2 cm swab in the left nostril and a 4 cm swab in the right nostril, or vice versa. All participants undergo a healthcare worker-collected throat swab for RT-PCR analysis, which serves as the reference standard for SARS-CoV-2 infection.
Age range
16 Years
Sex
ALL
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Diagnostic accuracy (sensitivity and specificity) of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs) using nasal swabs collected at 2 cm versus 4 cm insertion depth, with RT-PCR as the reference standard
Timeframe: Baseline (during the study visit at the time of sample collection). Ag-RDT results were available immediately, whereas RT-PCR results were reported the following days (1-3 days).