POD Risk for Colorectal Cancer Surgery (NCT07597330) | Clinical Trial Compass
CompletedNot Applicable
POD Risk for Colorectal Cancer Surgery
China590 participantsStarted 2024-01-01
Plain-language summary
Postoperative delirium is a common complication after colorectal cancer surgery that hinders recovery. This observational study hypothesizes that a simple, practical risk tool can be developed by combining preoperative clinical conditions, blood tests (including the TyG index), and clinical subtypes identified via clustering analysis. Investigators will enroll patients undergoing elective colorectal cancer surgery, assess delirium twice daily for 7 days postoperatively using the 3D-CAM, and finalize the scoring scale. It will help doctors quickly identify high-risk patients for targeted care to improve recovery. Only data will be collected; patients receive standard clinical treatment.
Who can participate
Age range
18 Years – 89 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Histologically confirmed colorectal cancer (colon or rectal cancer) via - preoperative or postoperative pathology;
* Scheduled for elective surgical intervention (open or laparoscopic resection);
* Preoperative Mini Mental State Examination (MMSE) score ≥18 (no pre-existing cognitive impairment);
* Able to provide written informed consent (self or legal representative);
* Complete preoperative clinical and laboratory data.
Exclusion Criteria:
* Postoperative pathology confirmed non-malignant tumor;
* Age ≥90 years old;
* Presence of visual, cognitive, language, or speech impairment; or history of neuropsychiatric diseases (dementia, Parkinson's disease, cerebrovascular accidents);
* No preoperative cognitive function assessment or MMSE score \<18;
* Emergency surgery or palliative surgery (non-curative resection);
* Postoperative admission to intensive care unit (ICU) (excluded due to different monitoring and intervention patterns);
* Missing key data \>5% (e.g., incomplete TyG index calculation, missing clustering analysis variables);
* Refusal to participate or inability to complete 7-day postoperative follow-up.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of Postoperative Delirium (POD) within 7 days after surgery
Timeframe: From postoperative day 1 to day 7 (or until hospital discharge if earlier)