Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers (NCT07597213) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers
Turkey (Türkiye)23 participantsStarted 2026-06
Plain-language summary
The goal of this clinical trial is to evaluate whether hyaluronic acid (HA) improves periodontal healing in people with periodontal disease who smoke. Moreover, the effects of HA on biomolecules and bacteria levels will be assessed during the follow up period.
The main questions it will answer are:
Will periodontal sites treated with HA gel after non-surgical periodontal treatment (NSPT) lead to better outcomes in clinical parameters compared to the sites treated with NSPT only in smokers?
Will adjunctive use of HA gel reduce oxidative stress markers and bacteria levels during follow-up?
Researchers will compare periodontal sites receiving NSPT with adjunctive HA gel application to sites receiving NSPT alone to determine whether HA provides additional clinical, biochemical and microbiological benefits.
Participants will:
* first receive full-mouth NSPT then, randomization will be performed in selected jaw to determine the test sites. These two interproximal test sites will additionally receive HA gel application.
* attend follow-up visits at 1, 3 and 6 months for clinical periodontal measurements and to provide gingival crevicular fluid samples (GCF) and subgingival samples.
The GCF samples will be evaluated for Metallothionein (MT) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and subgingival samples for periodontal pathogens.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Individuals who sign the informed consent form
. Participants who are systemically healthy
. Participants who smoke (for \>5 years and ≥10 cigarettes per day)
. Participants diagnosed with Stage III or Stage IV periodontitis
. Participants with at least 20 natural teeth present in the mouth (excluding third molars)
. Participants with two non-adjacent interproximal sites in each quadrant of either jaw, presenting probing depth (PD) and clinical attachment level (CAL) ≥6 mm, and with no caries, restorations, or furcation involvement
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically studying smokers with periodontitis — would my smoking history and current gum disease severity make this something worth discussing as a potential option for me?
2The trial is adding hyaluronic acid to standard non-surgical gum treatment and measuring things like probing depth and clinical attachment level — can you explain what those measurements mean for my gum health, and whether those are the outcomes most important for my situation?
3Since this trial isn't recruiting yet, how would standard non-surgical periodontal therapy compare to waiting for a study like this one, and is there a risk to my gum health in delaying treatment?
4This study is also looking at oxidative stress and oral bacteria changes in smokers — does that kind of information about my mouth's biology matter for how my periodontitis would be treated long-term?
5Given that this trial is listed as Phase NA, which often means it's exploratory or device-related rather than a later-stage drug trial, what does that mean about how much is already known regarding the safety and effectiveness of using hyaluronic acid this way?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Probing Depth (PD)
Timeframe: Baseline to 1, 3 and 6 months after NSPT.
2
Change in Clinical Attachment Level
Timeframe: Baseline to 1, 3 and 6 months after NSPT