Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics (NCT07596758) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics
Egypt22 participantsStarted 2026-05-14
Plain-language summary
The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with subepithelial connective tissue grafting in adults requiring single immediate implant placement.
Who can participate
Age range
20 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 20 to 45 years.
* Systemically healthy patients eligible for implant surgery.
* Patients requiring extraction of a single non-restorable tooth indicated for immediate implant placement.
* Implant sites located in the maxillary esthetic or para-esthetic zone.
* Sites with sufficient apical and/or palatal bone to permit correct three-dimensional implant positioning and achieve adequate primary stability.
* Sites suitable for simultaneous subepithelial connective tissue grafting.
* Patients with acceptable oral hygiene and good compliance with periodontal and implant treatment.
* Patients willing to attend all follow-up visits and comply with study instructions.
Exclusion Criteria:
* Medically compromised patients or patients with systemic conditions that may contraindicate implant surgery or interfere with healing.
* Smokers.
* Pregnant or lactating women.
* Patients with uncontrolled periodontal disease or poor oral hygiene.
* Patients with acute infection at the intended implant site.
* Patients with insufficient bone volume preventing immediate implant placement with adequate primary stability.
* Patients with a history of head and neck radiotherapy or chemotherapy.
* Patients receiving bisphosphonates or other medications known to affect bone metabolism or soft tissue healing.
* Patients with parafunctional habits that may jeopardize implant stability or restorative success.
* Patients unwilling or unable to complete the follow-up period…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
evaluation of matrix metalloproteinase-8 (MMP-8) levels