Not Yet RecruitingNot Applicable

Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT

1,000 participantsStarted 2026-12-01

Plain-language summary

This retrospective observational study evaluates physiological and cognitive changes following a series of 60 hyperbaric oxygen therapy (HBOT) sessions in healthy individuals. Participants underwent treatment five days per week, each session included 90 minutes exposure to 100% oxygen at 2ATA with a five-minute air break every 20 minutes. Pre- and post-treatment data include cardiopulmonary exercise testing (CPET) and standardized cognitive assessments. The study aims to characterize associations between changes in cardiorespiratory fitness and cognitive performance following repeated HBOT exposure in a real-world clinical cohort

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18-65 years * Completed a full treatment series of 60 hyperbaric oxygen therapy (HBOT) sessions at the Sagol Center * Availability of pre- and post-treatment cardiopulmonary exercise testing (CPET) data * Availability of pre- and post-treatment cognitive assessment data Exclusion Criteria: * Inability to complete a maximal CPET test, pre and post HBOT or Missing pre- or post-treatment CPET data. * Incomplete HBOT treatment series * Missing cognitive assessment data

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Exercise Duration During CPET

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Peak Workload During CPET

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Peak Metabolic Equivalent (METs) During CPET

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Ventilatory Threshold Oxygen Uptake (VT1/VT2)

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Ventilatory Threshold Workload

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Ventilatory Threshold Heart Rate

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Time to Ventilatory Threshold

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Trial details

NCT IDNCT07596641

SponsorAssaf-Harofeh Medical Center

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2027-12-01

Contact for this trial

Eldad Mr Yaakobo, Ms

+972542092860 yaakobi.eldad@gmail.com

View on ClinicalTrials.gov More Hyperbaric Oxygenation trials

Plain-language summary

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Exercise Duration During CPET

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Peak Workload During CPET

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Peak Metabolic Equivalent (METs) During CPET

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Ventilatory Threshold Oxygen Uptake (VT1/VT2)

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Ventilatory Threshold Workload

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Ventilatory Threshold Heart Rate

Timeframe: Baseline and post-treatment (approximately 4-6 months)

Time to Ventilatory Threshold

Timeframe: Baseline and post-treatment (approximately 4-6 months)