Tumor-informed MRD for Non-small Cell Lung Cancer (NCT07596433) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Tumor-informed MRD for Non-small Cell Lung Cancer
China450 participantsStarted 2022-02-18
Plain-language summary
The goal of this study is to evaluate the clinical utility of a personalized, WES-informed MRD detection approach in patients with early-stage non-small cell lung cancer, with a focus on its association with postoperative recurrence and prognosis, as well as its ability to predict recurrence earlier than imaging.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Histologically or cytologically confirmed non-small cell lung cancer (NSCLC);
. Newly diagnosed patients who are planned to undergo surgical treatment;
. Age ≥18 years, regardless of sex;
. Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0-1;
. Written informed consent must be obtained prior to any study-related procedures, sampling, or analyses; patients must be able to provide sufficient tissue and/or blood samples required for the study, with tumor cell content ≥20% as confirmed by pathological assessment;
. Ability to comply with study requirements, including assessment of treatment efficacy, adverse events, and prognosis;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
RFS is determined as the duration from the date of surgery to the date of first detected disease recurrence or metastasis or death from any cause, whichever occurs first.
Timeframe: From enrollment to the end of follow up at 3 years
Trial details
NCT IDNCT07596433
SponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
. Willingness to undergo next-generation sequencing (NGS) testing.
Exclusion criteria
. Patients unwilling to provide tissue and blood samples for genetic testing;
. Patients who are mentally or medically unstable, rendering them unable or unwilling to provide written informed consent;
. Patients deemed by the investigator to be unsuitable for participation in the study, or those with poor compliance with study procedures, restrictions, and requirements.