Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution (NCT07593014) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution
25 participantsStarted 2026-07-30
Plain-language summary
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes. The study will also examine whether creatine affects fluid balance, blood volume changes and exercise performance.
The main questions it aims to answer are:
Does creatine supplementation increase plasma volume and total body water during repeated heat exposure more than placebo? Does creatine supplementation improve exercise performance after heat acclimation more than placebo? Does creatine supplementation influence cardiovascular responses to heat stress?
Researchers will compare a creatine supplementation group to a placebo group to determine whether creatine changes the magnitude of heat acclimation adaptations.
Participants will:
Complete baseline measurements of body composition, hydration, blood markers, and exercise performance.
Consume either creatine monohydrate or a placebo supplement daily Complete repeated supervised exercise sessions in a controlled heated environment Undergo repeated assessments of body water, temperature, heart rate, and exercise performance throughout the study
Who can participate
Age range
18 Years – 27 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy biological males between 18 and 27 years of age
* Recreationally active males and varsity athletes
* Able to safely participate in moderate-intensity exercise and heat exposure
* Willing to maintain habitual diet and physical activity throughout the study
* Willing to refrain from additional dietary supplementation during study participation
* Able to attend all required laboratory visits and heat exposure sessions
* Able to provide informed consent
Exclusion Criteria:
* History of cardiovascular, metabolic, respiratory, renal, neurological, or heat-related illness
* Contraindications to exercise testing or heat exposure identified during health screening
* Current musculoskeletal injury limiting exercise participation
* Current use of creatine supplementation or inability to complete the required washout period
* Current use of medications or supplements known to affect hydration, thermoregulation, cardiovascular function, or exercise performance
* Known allergy or intolerance to creatine monohydrate, maltodextrin, or orange juice
* Inability to comply with study procedures or supplementation protocol
* Resting tympanic temperature ≥38.0°C prior to a heat exposure session
* Participation in another research study that may interfere with this protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Plasma Volume Change Following Heat Acclimation and Creatine Supplementation
Timeframe: Measured at baseline (pre-supplementation), after 7 days of creatine/placebo loading, and after 7 days of heat acclimation.