This observational study aims to evaluate the long-term effectiveness and safety of mepolizumab 300 mg/4 weeks in adults with eosinophilic granulomatosis with polyangiitis (EGPA) in the European real-life setting. The main questions it aims to answer are: * How effective is mepolizumab 300 mg/4 weeks over long-term follow-up in patients with EGPA? * How safe is mepolizumab 300 mg/4 weeks during long-term treatment? * What are the effects of switching mepolizumab dosage from 300 mg/4 weeks to 100 mg/4 weeks, or from 100 mg/4 weeks to 300 mg/4 weeks? Participants already receiving mepolizumab as part of routine clinical practice. Researchers will retrospectively collect demographic, clinical, laboratory, and treatment-related data from medical records. For patients starting mepolizumab 300 mg/4 weeks, data will be collected from treatment initiation and during follow-up up to 60 months. For patients who change mepolizumab dose, data will also be collected at the time of dose switch and 3 months later.
Age range
18 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Complete and Partial Response
Timeframe: Baseline and up to 60 months (at 3, 6, 12, 24, 36, 48, and 60 months)
Change in Lung Function
Timeframe: Baseline and up to 60 months (at 3, 6, 12, 24, 36, 48, and 60 months)
Disease relapses
Timeframe: Up to 60 months (assessed at 3, 6, 12, 24, 36, 48, and 60 months)
Respiratory Exacerbations
Timeframe: Up to 60 months (assessed at 3, 6, 12, 24, 36, 48, and 60 months)